| CALL-UP DATE | NAME | MWBL | B-T | DOB | MLB | YR | POS |
| 3/31/2008 | Fukudome, Kosuke | PIT | L-R | 04/26/1977 | chc | 07 | OF |
| 3/31/2008 | DeWitt, Blake | CCC | L-R | 08/19/1981 | lad | 06 | 3B |
| 3/31/2008 | Ramirez, Alexei | SEV | R-R | 09/21/1977 | chc | 08 | 2B |
| 4/01/2008 | Nix, Jayson | TEM | R-R | 08/26/1982 | col | 08 | SS |
| 4/01/2008 | Barton, Brian | CHI | R-R | 04/24/1978 | stl | 07 | OF |
| 4/02/2008 | Kobayashi, Masahide | FRE | R-R | 05/23/1970 | cle | 08 | P |
| 4/03/2008 | Cueto, Johnny | AAB | R-R | 02/14/1982 | cin | 07 | P |
| 4/04/2008 | Kuroda, Hiroki | PIT | R-R | 02/09/1971 | lad | 08 | P |
| 4/05/2008 | Yabuta, Yasuhiko | TEM | R-R | 06/18/1969 | kc | 08 | P |
| 4/06/2008 | Span, Denard | TEM | L-L | 02/26/1980 | min | 06 | OF |
| 4/12/2008 | Longoria, Evan | DET | R-R | 10/06/1981 | tb | 06 | 3B |
| 4/13/2008 | Niemann, Jeff | IRN | R-R | 02/27/1979 | tb | 07 | P |
| 4/15/2008 | Lowrie, Jed | LBD | S-R | 08/16/1980 | bos | 08 | SS |
| 4/17/2008 | Duran, German | IRN | R-R | 08/02/1980 | tex | 08 | 2B |
| 4/20/2008 | Burriss, Emanuel | TEM | S-R | 01/16/1981 | sf | 07 | SS |
| 4/24/2008 | Masterson, Justin | SAC | R-R | 03/21/1981 | bos | 08 | P |
| 4/26/2008 | Lillibridge, Brent | VIR | R-R | 09/17/1979 | atl | 07 | SS |
| 4/29/2008 | Scherzer, Max | TIJ | R-R | 07/26/1980 | arz | 06 | P |
| 5/01/2008 | Adenhart, Nick | YSS | R-R | 08/23/1982 | laa | 06 | p |
| 5/11/2008 | Reynolds, Greg | IRN | R-R | 07/02/1981 | col | 08 | P |
| 5/14/2008 | Arredondo, Jose | YSS | R-R | 03/29/1980 | laa | 07 | P |
| 5/16/2008 | Perez, Chris | PIT | R-R | 06/30/1981 | stl | 07 | P |
| 5/21/2008 | Denker, Travis | LBD | R-R | 08/04/1981 | sf | 06 | 2B |
| 5/25/2008 | Kershaw, Clayton | HOL | L-L | 03/18/1984 | lad | 07 | P |
| 5/27/2008 | Bruce, Jay | LBD | L-L | 04/02/1983 | cin | 06 | OF |
| 5/30/2008 | Gonzalez, Carlos | IRN | L-L | 10/16/1981 | oak | 06 | OF |
| 5/30/2008 | Larish, Jeff | FRE | L-R | 10/10/1978 | det | 08 | 1B |
| 6/05/2008 | Carter, Chris | CCC | R-R | 09/15/1978 | bos | 07 | OF |
| 6/08/2008 | Mock, Garrett | YSS | R-R | 04/24/1979 | was | 06 | P |
| 6/08/2008 | Tucker, Ryan | TOP | R-R | 12/05/1982 | fla | 07 | P |
| 6/12/2008 | Hurley, Eric | CAM | R-R | 09/16/1981 | tex | 06 | P |
| 6/22/2008 | Ramirez, Max | BUF | R-R | 10/10/1980 | tex | 06 | C |
| 6/26/2008 | Davis, Chris | HOL | L-R | 03/16/1982 | tex | 08 | 1B |
| 6/27/2008 | Barthmaier, Jimmy | SEV | R-R | 01/05/1980 | hou | 06 | P |
| 7/01/2008 | Balester, Collin | GCG | R-R | 06/05/1982 | was | 06 | P |
| 7/02/2008 | Bankston, Wes | KEN | R-R | 11/22/1979 | oak | 06 | 1B |
| 7/04/2008 | Brignac, Reid | SAC | L-R | 01/15/1982 | tb | 06 | SS |
| 7/04/2008 | Hundley, Nick | BUF | R-R | 09/07/1979 | sd |